The conservative Supreme Court dealt a significant blow to transgender Americans on Wednesday, issuing a sweeping decision that may have implications beyond the medical care that was at center of one of the court’s highest-profile disputes this year.

The U.S. Supreme Court upheld a Republican-backed ban in Tennessee on gender-affirming medical care for transgender minors on Wednesday in a setback for transgender rights that could bolster efforts by states to defend other measures targeting transgender people.

The U.S. Supreme Court said Tennessee did not violate the constitution by banning gender-affirming care for transgender minors. The case is sure to resonate nationally.