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The Chargers are missing both top running backs, Omarion Hampton and Najee Harris, and have to make the cross-country trip for an early start. Remember, the Dolphins have one of the best home-field advantages in the NFL in early season 1 p.m. games. They are in the shade and the visitors are baked in sunshine, with a forecast high of 85 degrees.
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2025 Week 6 NFL picks, odds, best bets from proven model: This 5-leg football parlay pays 25-1
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Newsweek Sports Betting Editor Tyler Everett gives out his NFL Week 6 best bets, including the Colts over the Cardinals.
Daniel Jones has settled in perfectly with Indy, and we expect the Colts’ pivot to lead an aerial assault against a vulnerable Cardinals secondary.
Our first read of the betting lines was another mixed bag. The Broncos’ spread did move from 5.5 down to 4 and even 3.5 in some spots, setting up a perfectly good middle spot for bettors.
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The Green Bay Packers traveled to the desert for Week 7 and escaped with a 27-23 win against the Arizona Cardinals. It was the second straight week the Packers faced a team without their starting quarterback and still required a strong finish to secure the victory.
The Rams beat the Ravens last week, while the Jaguars lost to the Seahawks. The Seattle line sacked Trevor Lawrence seven times in that game. The Rams' defensive front has to be licking its chops. The Los Angeles offense will be without Puka Nacua, its best receiver. That matters. The Jaguars will pull one out late.