Stem cells are defined by their self-renewal and multilineage differentiation capacities. Postnatally, multiple types of lineage-restricted stem cells have been defined in different tissues and organs ...

Cell- and animal-based models of bone formation reveal novel mechanisms involved in the cartilage-to-bone phenotype transition Animal studies have shown that some cartilage cells can transition to a ...

Skeletal bone is maintained by bone remodeling, in which old and damaged bone is replaced with new bone through continuous cellular processes that are mainly controlled by bone-resorbing osteoclasts ...