Investigators found important differences that may help clinicians better understand how to manage toxicities associated with the therapy. The toxicity profile of chimeric antigen receptor (CAR) T ...

CD22 Targeted Therapies Need & Why This Report? As the landscape of cancer therapies evolves, there is an increasing demand for treatments that specifically target the CD22 protein, which is found on ...

Investigators said longer-term outcomes from chimeric antigen receptor (CAR) T-cell therapies are still a significant question in patients who have non-Hodgkin lymphoma (NHL) or acute lymphoblastic ...

Philadelphia, January 4, 2022—Aberrant splicing of messenger RNAs encoding surface antigen CD22 leads to downregulation of this protein in pediatric B-lymphoblastic leukemia (B-ALL), rendering ...

In many neurodegenerative disorders, microglia come down with a kind of indigestion, and no longer degrade lipids and other molecules. In the December 1 Science Translational Medicine, researchers led ...

Robert J. Kreitman, M.D.: So, what was it like getting into the trial of an experimental drug for hairy cell leukemia after that experience with chemotherapy and rituximab? Vince Fazio: I was actually ...

Researchers have found that restoration of B cell function in BCR signaling deficiencies involves the interaction of CD22, normally an inhibitory factor, with binding partners on the same cell, which ...

CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced ...

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B ...