Ensuring accurate cell type annotation in single-cell RNA sequencing data is a significant challenge, as both expert and automated methods can be biased or constrained by their training data, leading ...
Understanding how rare genetic variants influence complex traits remains a major challenge, particularly when these variants lie in noncoding regions of the genome. The effects of variants within ...
Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...
Researchers headed by a team at the University of California, Irvine, Joe C. Wen School of Population & Public Health have built what they suggest is the first cell type-specific gene regulatory ...
In a recent study published in the journal Nature, researchers in Canada and the United States developed Single-Cell Similarity (SCimilarity), a framework for rapid, interpretable searches of ...
A detailed cellular study of Crohn's disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each ...
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