Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method automatically positioning ...

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer. DNA is well-known for its double helix shape. But the human genome ...

DNA's double helix has long stood as the symbol of life's code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

Single-molecule localization microscopy (SMLM) 1,2 overcomes the resolution limit of conventional light microscopy by switching on only a few fluorescent molecules at a time, so that their signals do ...

From endangered monkeys to struggling coral reefs, conservation genomics is giving scientists a new way to fight extinction. By decoding complete genomes, researchers can pinpoint traits that help ...

DNA methylation is an epigenetic modification crucial to normal development, with its dysregulation leading to various diseases including cancer. As interest in epigenomics grows, an innovative ...

New single-cell method maps protein-DNA interactions, revealing gene regulation changes and advancing multi-omics studies of health and disease. (Nanowerk News) A new technology allows scientists to ...

This image depicts the detection of structural variants (SVs) at low sequencing coverage in both unique and repetitive regions by genomic proximity mapping (GPM), compared with other SV-calling ...