New therapeutic approaches to resolve persistent pain are highly needed. We tested the hypothesis that manipulation of cytokine receptors on sensory neurons by clustering regulatory cytokine receptor ...

Cytokines are a group of small molecule proteins or polypeptides that are synthesized, stimulated, or secreted by immune cells (including monocytes, macrophages, T cells, B cells, NK cells, etc.) and ...

In this interview, News-Medical talks to Dr. Shuang Zhou about cytokine-base cancer immunotherapy, the current state of the field, and future prospects. Cytokines are molecular messengers released by ...

A comprehensive, multi-phase investigation published in Advanced Science suggests that the amino acid tryptophan (Trp) may be a key determinant of therapeutic response to conventional synthetic ...

CAR-T cell therapy has emerged as a transformative approach in treating B cell malignancies and multiple myeloma. However, this approach is in desperate need of refinement. While attacking tumor cells ...

The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Despite recent advances in our ...

Current cell therapies like CAR-T cells lack the precision to distinguish between healthy and diseased tissue, leading to limited effectiveness and potential side effects. One of the most significant ...