If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

DNA replication is the fundamental process by which cells duplicate their genetic material before division. Initiation occurs at defined origins where a hexameric helicase unwinds the double helix, ...

DNA unwinding and primer synthesis are fundamental processes in genome replication. The human herpes simplex virus type 1 (HSV-1) helicase-primase forms a unique heterotrimeric primosome that is ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...