Researchers at Penn Medicine have identified specific brain circuits that are impacted by psilocybin—the active compound found in some psychedelic mushrooms—which could lead to new paths forward for ...

Penn Medicine researchers have discovered that psilocybin, a natural compound found in some psychedelic mushrooms, can ...

A single psilocybin dose relieved chronic pain and depression-like symptoms in mice by rebalancing brain circuits that regulate mood and pain.

A new study reveals magic mushrooms' active compound, psilocybin, may ease chronic pain and depression. Experiments in mice ...

Penn Medicine researchers discovered that psilocybin can ease chronic pain and depression by subtly tuning serotonin activity ...

New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site ...

Researchers have uncovered a surprising link between chronic pain and mental health issues in a landmark study based on decades of research. Depression and loneliness are more common in people with ...

Clinical depression is often linked to aches and pains, including back pain. Having chronic back pain is also associated with worsening depression symptoms in some people. Research indicates there’s a ...

Network analysis highlights the strong, central roles of depression, anxiety, and pain disability in chronic musculoskeletal pain, forming a dense, interconnected psychological network.

Fibromyalgia and MDD share affective dysregulation, marked by impaired left amygdala downregulation and high stress reactivity, according to a multimodal study.

A new study has linked two types of depression, atypical and melancholic, to an increased risk of certain cardiometabolic ...

When I first entered the mental health field, I did not see physical pain as something I would treat. I understood that many of the individuals I encountered were dealing with pain. It's extremely ...