Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time. The proteins of the formin ...

Formins are conserved Rho-GTPase effectors that communicate Rho-GTPase signals to the cytoskeleton. We found that formins were required for the assembly of one of the three budding yeast actin ...

Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time. There are as many as 15 ...

Formins are a conserved family of actin-binding proteins that orchestrate the formation and elongation of unbranched actin filaments, thereby shaping the architecture and mechanical properties of the ...

Our lab is focused on the question of how cells dynamically assemble and reorganize their actin cytoskeletons to govern cell shape, cell movement, and cell division. Every cell type has a unique ...

The dynamic processes that occur during the growth of actin, via polymerization, and the breakdown of actin both play significant roles in cellular mechanisms like migration and adhesion. Due to the ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Formins are made of two identical parts (red, orange) that encircle the actin (grey) filament in a ring-like conformation. “Our discovery allows us to interpret decades of biochemical studies on ...