Every year, life-threatening invasive fungal infections afflict more than 2 million individuals globally. Mortality rates for these infections are high, even when patients receive treatment.

β-1,3 Glucan synthase (GS) is essential for fungal cell wall biosynthesis. The GS holoenzyme comprises the glycosyltransferase FKS1 and its regulatory factor Rho1, a small GTPase. However, the ...

The fungal cell wall is a dynamic, multilayered structure essential for growth, morphogenesis, environmental adaptation and host interaction. Its core framework comprises chitin and ...

Fungi are everywhere, and in many cases, a fungal infection can be eliminated by a person's immune system. But fungal infections can also send long hyphae into the body that are extremely difficult to ...

A recent study has shed light on the transcriptional regulatory mechanisms of Penicillium expansum, the fungal culprit behind blue mold disease in fruits. By mapping chromatin accessibility at ...

Fungi have been around for many millions of years, with the incremental process of evolution honing and improving their survival skills through the millennia. Now, Binghamton University researchers ...

Invasive fungal infections pose a significant global health challenge due to their severity and the scarcity of effective and safe treatment options. Unlike antibacterial drug development, creating ...

Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group, in 2022, approximately 6.5 million people were infected by a pathogenic fungus, and about 3.8 ...

Two new research studies are addressing the rising threat of fungal infections, which can be very difficult to treat. One study has examined the cell walls of fungi to look for weaknesses, while ...