When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

When bacteria cells replicate, they do so a little differently than human cells do. They don't undergo mitosis, a splitting that involves construction of spindles to carefully separate the DNA after ...

DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Bacterial DNA replication is a highly coordinated process that ensures faithful genome duplication and cell division. Replication initiates at a single chromosomal origin (oriC) where multiple copies ...