Self-labeling protein tags such as SNAP-tag offer the opportunity to attach bright and photostable synthetic fluorophores to proteins of interest for later analysis, and are widely used in ...

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility. Using the ...

Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could label proteins in millions of cells. Conventional protein-tagging methods, ...

Determining the label to target ratio, also known as the degree of labeling (DOL), is crucial for quantitative fluorescence microscopy and a high DOL with minimal unspecific labeling is beneficial for ...

Tissue processing advance can label proteins at the level of individual cells across whole, intact rodent brains and other large samples just as fast and uniformly as in dissociated single cells. A ...