There are just two games between ranked teams as No. 16 Vanderbilt visits No. 10 Alabama and No. 3 Miami heads to No. 18 Florida State. The latter game was heading toward a matchup of top-10 teams before the Seminoles lost at Virginia in Week 5.

Northwestern has won three straight after Saturday’s stunning win at Penn State that resulted in James Franklin getting fired. Purdue is still searching for its first Big Ten win since 2023. Ohio State has failed to cover just one this season. Wisconsin is a mess, with a 37-0 loss to Iowa the latest example. Luke Fickell’s job is in jeopardy.

The SportsLine projection model has revealed its Wisconsin Badgers vs. Ohio State Buckeyes picks for Saturday on CBS and Paramount+

The Cyclones are underdogs in this one. Cincinnati has flown under the radar thanks to its Week 1 loss to Nebraska. A win would move Iowa State to 3-0 in Big 12 play after its Week Zero win over Kansas State and a 39-14 victory over Arizona in Week 5.

Desmond Williams Jr. is becoming a star, throwing for 402 yards and two touchdowns against the Scarlet Knights while rushing for 136 yards and two scores. The Huskies are third in the conference in offense and could be a wild card the rest of the season, especially if they can upset the Wolverines on Saturday.