Nature

Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy

This study investigated the effects of indirubin on autophagy and apoptosis in cervical cancer models, with a focus on elucidating the underlying molecular mechanisms. A xenograft tumor model in ...
Nature

PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways

The development of chemoresistance is a major challenge in the treatment of several types of cancers in clinical settings. Stemness and chemoresistance are the chief causes of poor clinical outcomes.
Medscape

Low-Dose Aspirin Cuts CRC Recurrence

Low-dose aspirin reduced colorectal cancer (CRC) recurrence rates by more than half in patients with tumors harboring mutations in the PI3K signaling pathway, according to findings from the phase 3 ...
ascopubs.org

Artificial intelligence–enhanced biomarker analysis of WNT, TGF-β, and PI3K pathway alterations in FOLFOX-treated early-onset colorectal cancer in high-risk populations.

WNT pathway alterations in bevacizumab-treated early-onset colorectal cancer: An artificial intelligence–driven and disparity-aware precision oncology analysis. Longitudinal clinical validation of the ...
News-Medical.Net

Study identifies new therapeutic candidate for KRAS-driven pancreatic cancer

A new research paper was published in Volume 17 of Oncotarget on June 3, 2026, titled "The anticancer effects of PCAIs in ...
EurekAlert!

Experimental compounds trigger cancer cell death in KRAS-driven pancreatic cancer

Figure 10: Biochemical effects of PCAIs on cancer cells. PCAIs-treated cancer cells show the depletion of the monomeric G-proteins RAC1 and RHOA. MAPK and PI3K/AKT signaling pathways are activated ...