Given the inaccessibility of the living human brain, biobanks containing brains from human donors are critical for psychiatric research. Interest in postmortem tissue samples has accelerated in recent ...

A risk model that combines a mammographic artificial intelligence (AI) risk score with polygenic and clinical risk scores ...

Investigators evaluated polygenic risk score (PRS) models as a risk stratification tool in Black women with an enriched family history for overall breast cancer and triple-negative breast cancer.

Mammograms contain imaging biomarkers that can predict future breast cancer risk using deep learning (DL) models. We evaluated whether adding a polygenic risk score (PRS) improves performance of the ...

Polygenic risk scores (PRSs) are estimates of an individual's susceptibility to a specific complex trait obtained by aggregating the effects of dozens, thousands, and potentially millions of genetic ...

Incorporating a polygenic risk score into prostate cancer screening could enhance the detection of clinically significant prostate cancer that conventional screening may miss, according to results of ...

“What makes the score so powerful is its ability to predict, before the age of five, whether a child is likely to develop obesity in adulthood, well before other risk factors start to shape their ...

Similar to the way the caps on the ends of a shoelace prevent it from fraying, telomeres—regions of repetitive DNA sequences and a protein structure—protect the tips of chromosomes from damage. Every ...

A new analysis explores the genetic liability of psychiatric disorders using polygenic scores and recurrent copy number variants.

Tapping into the Million Veteran Program, an ongoing national research effort to learn how genes, lifestyle and military exposures affect the health of participants, researchers at University of ...

Using polygenic risk scores along with positive family histories and breast cancer-associated gene mutations improves risk stratification for breast cancer screening. Compared with a lower polygenic ...