Through her two marriages, Rosie O'Donnell has adopted four children and championed adoption rights for same-sex couples. Learn more about her family here.

Rosie O'Donnell revealed why Keanu Reeves struggled during an interview on her former talk show and called him 'one of the worst' guests she had

Comedian Rosie O’Donnell has revealed which Hollywood A-list star was her worst TV talk-show guest. The Rosie O’Donnell Show ran for almost 1,200 episodes between 1996 and 2002. During an interview on the Australian talk show Sam Pang Tonight this week, O’Donnell revealed that one guest in 1997 was her least favorite—Keanu Reeves.

The former talk show host immediately gave credit to her pick for his more redeeming qualities Frank Micelotta/Getty Rosie O'Donnell is opening up about her experience on her talk show. The Rosie O'Donnell Show aired for 6 seasons from 1996 through 2002.

Of all the many stars Rosie O’Donnell has interviewed, her pick for the worst guest on her show has utterly surprised fans. The comedian, 63, said it was none other than Keanu Reeves, who is widely regarded as one of Hollywood’s nicest guys.