The choice of an optimal marker strategy while analysing intragenic SNPs is presently of crucial importance, given the increasing amount of available data. Classical case/control association studies ...

The major histocompatibility complex (MHC), an immune gene-dense region on Chromosome 6p21.3, 1 is a prime candidate for disease association studies. Examples of clinical conditions associated with ...

To date, most marker-trait associations have been revealed using QTL and genome-wide association studies (GWAS), demonstrating both their successes and their limitations. Haplotypes are the particular ...

Objectives: Discrete blocks of low haplotype diversity exist within the human genome. The non-redundant subset of ‘haplotype tagging’ single nucleotide polymorphisms (htSNPs) in such blocks can ...

Five variants of a lipid transporter gene associated with an increased risk of developing type 2 diabetes among Mexicans and other Latin Americans are also seen in a Neanderthal genome sequence, ...

Long-read sequencing was declared the method of the year for 2022 and, indeed, has fully arrived on the computational biology scene. Specifically, Oxford Nanopore Sequencing technology has enabled ...

Flex-Seq® Ex-L offers targeted, fast, and effective sequencing-based genotyping to characterize upwards of 40,000 loci in plants and animals, such as maize, cotton, cattle, and pig. By sequencing a ...

Wednesday, April 2, 2008 –The Y chromosome retains a remarkable record of human ancestry, since it is passed directly from father to son. In an article published online today in Genome Research ...

Mice and rats are a fundamental component of drug discovery research. Standard outbred stocks and inbred strains of rodents are used extensively for drug safety and pharmacokinetic testing. Our ...

Scientists have known for years that the common H1 haplotype of the tau gene MAPT somehow raises a person’s risk of the rare neurodegenerative disorder progressive supranuclear palsy (PSP). It does so ...

Background: The measles virus (MV) interacts with two known cellular receptors: CD46 and SLAM. The transmembrane receptor CD209 interacts with MV and augments dendritic cell infection. Methods: 764 ...