Background and aims: Pro-inflammatory cytokines are the main mediators of juvenile idiopathic arthritis. Modern therapeutic strategies (biologicals) are therefore geared to block the action of ...

For these reasons, manipulation of proinflammatory cytokine levels is a tempting therapeutic target. Etanercept is a dimeric fusion protein consisting of the extracellular ligand-binding portion of ...

Researchers have shown that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease, an inflammatory condition that develops in ...

Cytokines are small, secreted proteins that transmit messages between cells and members of this superfamily include chemokines, growth factors, interleukins, interferons, colony stimulating factors, ...

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Immune-mediated inflammatory diseases (IMIDs) are a heterogeneous group of diseases characterized by chronic inflammation and organ damage. IMIDs were traditionally classified on the basis of the ...

“We’re witnessing a renaissance in cytokine targeting,” says Dr. Emily Rhodes, immunologist at the Stanford Institute for Translational Medicine. “And TNF-α is still the most contested—and the most ...

Molecular subtyping of colon cancer (CC) based on mutational status of RAS, BRAF, and DNA mismatch repair (MMR) proteins. Prognostic value. The role of depth of response and single-nucleotide ...

A small number of people who recover from coronavirus disease 2019 (COVID-19) experience long COVID — persistent symptoms that range from neurological issues to fatigue. The underlying cause behind ...

Psoriasis, a chronic inflammatory skin condition characterized by dry and scaly skin lesions, affects about 7.5 million people in the United States. Psoriasis results from abnormal proliferation of ...

Positive clinical data validates current Phase 2b clinical trial of isomyosamine as a treatment for chronic inflammation associated with muscle loss BALTIMORE--(BUSINESS WIRE)--TNF Pharmaceuticals, ...