New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1. The length of ...

Our DNA is arranged into chromosomes that carry a kind of protective shield at their ends, called telomeres. These protective caps are crucial to the stability of chromosomes, and when telomeres ...

New research linking telomere shortening to myelodysplastic syndromes (MDS) offers substantial therapeutic implications for affected patients and MDS research. In a previous study, the current authors ...

The University of Wisconsin’s Lim Lab has identified the cause of chromosome instability associated with a range of genetic diseases. Their findings, published in Science, attributed dysfunction in a ...

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...

This article and associated images are based on a poster originally authored by O Manners, G Pergl-Wilson, T Khanam, H Weisser, T Samuels, H Fischl, J Thottachery, M Pawlowska, S Ashraf, B Andrews, H ...

Loss of the DNA repair gene RNase H2 and a unique subset of DDR-deficient leiomyosarcomas. Phase 1 trial of avelumab with hypofractionated thoracic radiation therapy (HT-RT) in patients with ...

A study published in Ecological and Evolutionary Physiology reveals a surprising link between cellular aging markers and survival in black-legged kittiwakes (members of the gull family). In the work ...

CST (purple/lavender) bound to POT1 (red). Phosphorylation of the crimson-highlighted region in POT1 regulates the recruitment and activity of CST–Polα-primase at telomeres. The length of telomeres ...