A causative role for Notch signalling is well established in T cell acute lymphoblastic leukaemias (T-ALLs), which have activating mutations in the Notch genes resulting in a constitutively active ...

Notch signalling is involved in the cell-cell communication process via influencing the patterns of gene expression and differentiation. Notch pathway maintains stem cell populations and regulates ...

The role of the Notch pathway during animal neural development is best understood in fruit flies, where Notch has been shown to inhibit differentiation by lateral signaling and regulate cell fate ...

The notch signaling pathway plays a major role in regulating various cellular processes during development, therefore dysregulation of this pathway can lead to disease. This basic signaling pathway ...

Leaders carry a rewarding but heavy responsibility on their shoulders. In addition to setting the direction for their organization and implementing concrete plans to meet goals, they must also ...

Coordinated development requires that cells communicate with each other. This is made possible by molecular mechanisms of cell-cell signaling, by which cells can influence each other’s fate and ...