The then No. 20-ranked USC Trojans went on the road to South Bend, Indiana, to take on their heated rival and national contender, the No. 13-ranked Notre Dame F

No. 20 USC football failed to convert multiple scoring opportunities en route to its second loss of the season to Notre Dame.

The USC Trojans have a potent offense, and our expert college football predictions expect that offense to keep it close enough to cover the spread against Notre Dame!

Before the No. 20 USC Trojans take on the No. 13 Notre Dame Fighting Irish on the road, legendary Alabama coach turned TV analyst Nick Saban appeared on The Pat McAfee Show and gave his impression of USC's 2025 team.

Week 6 of the college football season provided fans with several shocking moments. On Saturday, arguably the biggest upset of the season took place as the UCLA Bruins shocked the No. 7 Penn State Nittany Lions 42-37 to earn their first win of the season.

Michigan’s passing attack was stifled in a 27-17 loss to the Washington Huskies last season that was led by former Wolverines QB Jack Tuttle. Tuttle lost a fumble, threw an interception and had just 98 passing yards during a Huskies revenge game for their 2023-24 NCAA title game loss.

Get our best USC vs. Notre Dame predictions, expert picks, and odds for college football Week 8 action on Saturday, October 18. USC will cover the spread.