The Wildcats desperately need to get back on track against the Buffaloes. Here's three guys to pay attention to on offense this Saturday.

Colorado is a four 1/2-point underdog against Arizona. What do we predict will be the final score in Colorado-Arizona?

The Buffaloes and Wildcats will kick off at 5 p.m. MT on Fox Sports 1. However, if the World Series does not go to a Game 7 (tentatively scheduled for a 6 p.m. MT first pitch on Saturday), the Colorado-Arizona game will be broadcast on Fox. The game will also be available to stream on Fubo and the Fox Sports app.

Pick OU: Under (53.5) Arizona has covered the spread three times in six games. Arizona is unbeaten ATS (2-0) as a 4.5-point favorite or greater this season. Out of six Arizona games so far this season, three have gone over the total. Colorado's record against the spread in 2025 is 4-4-0.

A look at the Arizona Wildcats so far in 2025 and what the Buffs and Deion Sanders should be expecting to see in Week 10.

Find single game tickets to the Arizona Wildcats vs. Colorado Buffaloes college football Week 10 matchup on Saturday, November 1, 2025 at Folsom Field.

Arizona head coach Brent Brennan shared his thoughts on Colorado and what he expects for Saturday evening's game against the Buffaloes in Boulder.

Arizona boasts the seventh-ranked defense in the Big 12, holding opponents to minimal yardage by meeting them behind the line of scrimmage. It is Arizona's aggressive defense that has the Wildcats tied for 14th in the FBS in tackles for loss.