Despite extensive PI3K/AKT/mTOR inhibitor development efforts, only a limited number of compounds have been approved by the US Food and Drug Administration (FDA) (Table 1). The mechanistic target of ...
Osteoarthritis (OA) is a common degenerative disease characterized by chondrocyte death and extracellular matrix (ECM) degradation, but the present OA treatments are only symptomatic and not ...
A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its potential ...