Abstract. PD-L1 is an established immunotherapy target highly expressed in various solid tumors, while B7-H3 is another extensively investigated target overexpressed on a wide range of tumor cells.
Cancer Res (2024) 84 (7_Supplement): ND08. The glycosphingolipid GD2 is a cell membrane component of a limited number of normal tissues including nerve cells, melanocytes or lymphocytes. However, in ...
Cancer Res (2024) 84 (6_Supplement): 3317.
Abstract. Activating mutations in the epidermal growth factor receptor (EGFR) gene occur in 10-20% of Caucasian and 40% of Asian non-small cell lung cancer (NSCLC) patients. Predominant ones among ...
Abstract. CUB domain containing protein 1 (CDCP1) is a single transmembrane protein that is highly expressed in a broad range of solid cancers, including lung, breast, colorectal, pancreas, prostate, ...
Abstract. KSQ-001EX is an engineered TIL (eTIL) therapy with CRISPR/Cas9-mediated inactivation of SOCS1, a negative regulator of cytokine signaling and T cell function. SOCS1 was identified in a ...
HER3 is a unique EGFR family member that plays a role in both tumor progression and drug resistance. Its expression can act as a bypass mechanism for EGFR and HER2-targeted therapies, resulting in ...
Background: GDF15 is overexpressed in solid tumors, with immunosuppressive effects on dendritic cells (DCs), T cells and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment. AZD8853 ...
CRISPR screens are a powerful discovery engine for biological research and have been extensively used for drug target discovery and validation. Pooled screens are advantageous because they can easily ...
AbstractIntroduction:. Trophoblast cell-surface antigen 2 (Trop-2) has become an attractive antibody drug conjugate (ADC) target as it is expressed in multiple solid tumors. Sacituzumab govitecan (SG) ...
Split-Screen Open the PDF for AACR Cancer Progress Report 2026AACR Cancer Progress Report 2026 in another window Share Tools ...
Abstract. The identification of immunogenic cancer epitopes, including patient-specific neoepitopes and shared tumor-associated antigens (TAAs), is a critical foundation for advancing effective cancer ...
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