The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

This important study demonstrates the significance of incorporating biological constraints in training neural networks to develop models that make accurate predictions under novel conditions. By ...

Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.

This valuable study concerns a model for transgenerational epigenetic inheritance, the learned avoidance by C. elegans of the PA14 pathogenic strain of Pseudomonas aeruginosa. A recent study ...

Caffeic acid phenethyl ester treats Clostridioides difficile infection by neutralizing Clostridioides difficile toxin B and altering the gut microbiota and metabolites.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States ...

This useful manuscript addresses a stability issue for long-term chronically implanted array recordings and electrolytic lesioning, which is relevant to both basic science and translational research.

This important study presents a compelling theoretical framework for understanding phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By ...

CPGs. Their model shows that cell-type-specific connectivity and a dominant inhibitory drive could underlie rhythm generation. Excitatory input could act to enhance the frequency range of these ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

Experiments in mice reveal how three rare mutations in a gene called TRIO can lead to different neurodevelopmental outcomes.

Researchers have used high-throughput neutralisation assays to reveal how gaps in individual immunity shape the success of circulating flu strains.