During ARIA, immune cells march from blood to brain. What sparks this mobilization? Scientists led by Moustafa Algamal, Mariel Kozberg, and Brian Bacskai at Mass General Brigham investigated this ...

Ask a clinician or a researcher about the blood-brain barrier (BBB) in Alzheimer’s disease, and you may hear about amyloid or leaky tight junctions. Fibronectin, a major scaffold protein, won’t ...

Scientists have created a mouse with a cortex largely made up of human neurons. After deleting most glutamatergic neurons in the mouse neocortex and hippocampus, Sergiu Paşca and colleagues at ...

Shape-shifting cells may explain why APOE4 carriers are at greater risk of cerebrovascular disease. In the 24 September Cell, scientists led by Joel Blanchard at the Icahn School of Medicine at Mount ...

Scientists show off new ways to biochemically probe tiny pieces of brain tissue taken from living people. In the September 24 Nature Communications, Ross Paterson and Aram Aslanyan at University ...

Amyotrophic lateral sclerosis is brutal. Familial mutations cause about one in 10 cases, of which fewer than 1 percent are due to an autosomal-dominant mutation in CHCHD10. Yet one carrier of a ...

Could a pool of largely overlooked proteins play a crucial role in disease? Growing evidence suggests that human cells make thousands of “microproteins,” i.e., peptides smaller than 150 amino acids, ...

Despite the batch of positive studies, “The current evidence still doesn’t support a protective effect of HRT on dementia risk,” said Kejal Kantarci of the Mayo Clinic in Rochester, Minnesota.

APOE4 is the strongest genetic risk factor for late-onset Alzheimer’s disease, so why do some carriers live long lives free of dementia? Scientists know that other genetic variants modulate APOE risk.

This humanized IgG1 antibody inhibits an immune checkpoint protein called programmed death ligand, aka PD-L1, stimulating the immune system. Checkpoint inhibitors, including other antibodies, are ...

Grand Prize: $30,000 plus travel to the 2026 awards; winning essay published in Science (print and online); 5-year digital subscription to Science. Runners up: $10,000; winning essay published in ...