My leg twitched for a year and a half. A complete record of the two years I spent believing I had ALS after losing my grandfather to the disease

IntroductionTwo years ago, while lying in bed on a trip, the muscles in my leg began to twitch.I knew what those symptoms ...
BIOENGINEER

Long-Read Sequencing Steps Into the Clinic for Spinal Muscular Atrophy Diagnosis

A new clinical study shows that third-generation long-read sequencing matches conventional tests perfectly while revealing ...
BIOENGINEER

AI Models Mine Blood Gene Data to Uncover New ALS Biomarkers

A computational study combining RNA sequencing of blood samples with machine learning and rigorous batch correction has ...
Planet Rugby on MSN

Who’s hot and who’s not: ‘Statement’ Wallaby win, ‘unmistakable difference’ Springboks can’t ignore and ‘unwanted’ Irish clean sweep

It’s time for our Monday wrap of who has their name in lights and who is making the headlines for all the wrong reasons after the weekend.
Medical Xpress

Base editing corrects mutation and slows motor neuron disease in mouse model

In a study published in Molecular Therapy Advances a team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi ...
The Lancet

A trembling detour to the diagnosis of encephalitis: a neuroborreliosis case report

In this Clinical Rounds, we present a case of neuroborreliosis in a man aged 59 years who initially complained of headache, ...
Healio

FDA approves Isembyld, first treatment to target muscle in spinal muscular atrophy

Please provide your email address to receive an email when new articles are posted on . Isembyld is approved for all adults and children aged 2 years and older. In a trial, participants saw a gain of ...
Yahoo News Australia

Princess Anne steps out to support MND charity

Add Yahoo as a preferred source to see more of our stories on Google. Princess Anne meets Sir Kevin Sinfield as he attempts to complete seven marathons in seven days to raise awareness of Motor Neuron ...
Hosted on MSN

First drug to target the muscle in spinal muscular atrophy wins approval

The FDA approved ISEMBYLD (apitegromab-mstn) on Sept. 11 for adults and children aged two and over with SMA who are already taking an SMN2-targeted treatment. In the Phase 3 SAPPHIRE trial, patients ...
Medscape

FDA OKs First Drug to Target Muscle Loss in Spinal Muscular Atrophy

The FDA has approved the first therapy for spinal muscular atrophy (SMA) that directly targets muscle loss, providing a complementary approach to existing treatments that target motor neuron survival.
Nature

First for RNA therapy: man with rare motor-neuron disease improves after treatment

A man with an uncommon type of motor neuron disease experienced improved symptoms and continued to work as a physician a year after becoming the first person to receive a drug designed to target the ...
Nature

Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease

A collaborative project from the PsychAD Consortium has compiled RNA-expression (transcriptomic) data from millions of individual brain cells in samples provided by nearly 1,500 people. Writing in ...