Through her two marriages, Rosie O'Donnell has adopted four children and championed adoption rights for same-sex couples. Learn more about her family here.

Rosie O'Donnell revealed why Keanu Reeves struggled during an interview on her former talk show and called him 'one of the worst' guests she had

The former talk show host immediately gave credit to her pick for his more redeeming qualities Frank Micelotta/Getty Rosie O'Donnell is opening up about her experience on her talk show. The Rosie O'Donnell Show aired for 6 seasons from 1996 through 2002.

Comedian Rosie O’Donnell has revealed which Hollywood A-list star was her worst TV talk-show guest. The Rosie O’Donnell Show ran for almost 1,200 episodes between 1996 and 2002. During an interview on the Australian talk show Sam Pang Tonight this week, O’Donnell revealed that one guest in 1997 was her least favorite—Keanu Reeves.

Rosie O’Donnell is asking for prayers for her 28-year-old daughter, Chelsea, who has had multiple felony charges in the past few years and was recently sentenced to time in prison. On Oct. 29, the comedian and former talk show host uploaded a childhood photo of Chelsea to Instagram and asked for prayers in the caption.

O'Donnell also revisited her infamous interview with Tom Selleck, in light of the actor's support for the National Rifle Association.