As the Indianapolis Colts look to keep their playoff hopes alive, up next for them is a home matchup with the San Francisco 49ers on Monday Night Football. So, who has the advantage in the key areas of this game?

An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason hopes.

Two teams that could be interested? The Pittsburgh Steelers and Indianapolis Colts. The Steelers will likely be looking to replace Aaron Rodgers, assuming he indeed does retire. The Colts will need at least a fill-in for Daniel Jones after his torn Achilles.

ESPN's Field Yates shared his first-round prediction for the San Francisco 49ers in a way-too-early 2026 NFL mock draft.

QB Mac Jones could draw major offseason trade interest after impressing in relief of Brock Purdy, according to an NFL insider.

The Indianapolis Colts and Pittsburgh Steelers could be in the market for a quarterback in 2026 and that makes a trade for San Francisco 49ers signal-caller Mac Jones a possibility.

The San Francisco 49ers got a crucial update on former first-round WR Ricky Pearsall's injury status, courtesy of HC Kyle Shanahan.

Game summary of the Chicago Bears vs. San Francisco 49ers NFL game, final score 41-10, from October 29, 2006 on ESPN.

That is, until now. Eddy Pineiro has been revolutionary for the 49ers and has been key to the 49ers' success this season. Nick Wagoner of ESPN is urging the 49ers, amid this breakout season for Pineiro, to lock up their franchise kicker to a long-term deal.