Here is a complete guide to picking No. 5 Oregon vs. No. 12 Liberty in your 2025 March Madness bracket, including updated odds and our expert predictions for the East Region game.
The 5-12 upset is the most popular NCAA first-round pick, and for good reason. Colorado State leads this year's group of 12-seed upstarts as an outright favorite to beat its 5-seed opponent.
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