Gut

Expert consensus on clinical trials for use of systemic therapy in patients with hepatocellular carcinoma undergoing surgical and locoregional therapies

Background Advances in systemic therapy for advanced hepatocellular carcinoma (HCC) have fuelled a growing interest in ...
Gut

Metastatic pancreatic cancer: from human disease to preclinical modelling

Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid cancers, portending poor patient outcomes ...
Gut

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone ...
Gut

Eosinophilic gastritis: burden of disease, diagnostic challenges and unmet needs

Eosinophilic gastritis (EoG) is a rare, chronic disease characterised by pathological eosinophilia of the stomach and ...
Gut

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma ...
Gut

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic ...
gut.bmj

Impact of non-enteric-coated pancreatic enzyme replacement therapy (NEPERT) on pain in patients with chronic pancreatitis: a double-blind, parallel-group, placebo-controlled ...

Background Pain in chronic pancreatitis (CP) is multifactorial. Efficacy of pancreatic enzyme replacement therapy (PERT) for pain remains uncertain. Objective To assess the effect of ...