Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Single cells are typically typed by clustering into discrete locations in reduced dimensional transcriptome space. Here we introduce Stator, a data-driven method that identifies cell (sub)types and ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

Spatial proteomics (SP) encompasses a diverse array of technologies that vary in scale, resolution, and sensitivity, offering researchers and clinicians a broad range of tools to investigate the ...

In response to infections, naive CD8 T cells give rise to effector and memory T cells. However, eliciting long-lived memory CD8 T cells remains a challenge for many infections. DNA demethylation of ...

The general transcription machinery and its occupancy at promoters are highly conserved across metazoans. This contrasts with the kinetics of mRNA production that considerably differ between model ...

Signaling pathways play a major role in P-body dynamics and different protein kinases have been functionally associated with the regulation of P-body assembly/disassembly (Rzeczkowski et al, 2011; ...

Corneal diseases can cause severe visual impairment and even blindness, which have been linked to the interruption of corneal epithelial homeostasis. However, the underlying molecular mechanisms are ...

Metastatic progression can be associated with the acquisition of genetic, epigenomic, and metabolic characteristics that foster a tumor cell’s ability to break out of the primary site. One of the key ...

After the Covid-19 pandemic, pertussis has made a spectacular comeback in Europe and many other parts of the world, while during the pandemic it had essentially disappeared because of the social ...

Here, we report that nTRIP6 is expressed by alternative translation initiation at an internal AUG and that a short open reading frame (ORF) within the Trip6 coding sequence represses nTRIP6 ...

The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through ...