A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were ...

When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self.

A new European Union regulation introduces a centralized clinical assessment process for comparing the effectiveness and safety of new medicines with those of the standards of care in various ...

A 51-year-old man presented with a 2-hour history of coffee-ground emesis and difficulty swallowing. Upper endoscopy showed black discoloration and friability of the mucosa from the midesophagus to ...

Whether screening with blood-based early-detection tests for multiple cancers in addition to usual care has clinical utility is unknown. In a randomized, controlled trial conducted in England, we ...

Settlements of lawsuits against opioid manufacturers and other entities will shape drug policy for decades. Attention is needed to ensure that the funds will be dedicated to evidence-based activities.

Arterial Line Placement (Introduction) This video will demonstrate arterial line placement in the radial artery using two of the many techniques available for arterial line placement, an over-the-wire ...

Competition is vital to the success of Medicare Advantage but is limited. As the program grows rapidly under favorable payment policy, a reformed traditional Medicare could provide valuable competi ...

To address drivers of poor child health, society should move from responding to health crises one symptom and one child at a time to reimagining ecosystems in ways that facilitate healthy development.

Acute metabolic acidosis is common in hospitalized patients owing to conditions such as shock, kidney disease, and diabetic ketoacidosis. While the underlying cause is being treated, it may be ...

Gene therapy can spare people with sickle cell disease from recurrent vaso-occlusive crises, but for the populations that bear most of the global burden of disease, there’s no pathway to such treat ...

Colonoscopy surveillance after the removal of adenomas is a cornerstone of the prevention of colorectal cancer. Guidelines in the United States and Europe have endorsed surveillance beginning at 3 ...