Analyzing Monday’s Jacksonville Jaguars at Buffalo Bills odds and lines, with expert NFL picks and predictions.

After an all-out sprint through their first two games and having two wins to show for it, the Bills have had 10 full days to ...

Mitch Morse expects a “different opportunity” when he experiences Highmark Stadium as a visitor for the first time ...

The Buffalo Bills will try to move to 3-0 and keep the Jacksonville Jaguars winless when they meet in a key AFC matchup on ...

Josh Allen has a losing regular season record against just three NFL teams. One is the Jacksonville Jaguars. Allen is 1-2 in ...

Cooks picked up 3.8 fantasy points -- three catches, 38 yards -- in Week 16 against the Tampa Bay Buccaneers, his best game ...

Buffalo Bills head coach Sean McDermott spoke about veteran defensive end Dawuane Smoot, who is set to make his debut for the team this week.

Bills/Sabres owner Terry Pegula is thankful to have Guelli in place, and Guelli hopes this is the final stop of a journey ...

Our computer prediction projects a lopsided win (28-14) for the Buffalo Bills (2-0) over the Jacksonville Jaguars (0-2) on ...

Also keep in mind that Buffalo has been one of the league’s best teams on both sides of the ball so far, ranking third in ...

Where does the Buffalo Bills' starting cornerback duo of Christian Benford and Rasul Douglas rank among the rest of the NFL?

Buffalo Bills running back James Cook could be the key to the AFC East champs continuing their early season dominance.