The Indianapolis Colts will enter their Monday Night matchup against the San Francisco 49ers as the home underdogs. At 8-6 on ...

We used the ESPN Football Power Index's most likely simulation to project Weeks 16, 17 and 18 -- and how the NFL playoff ...

Williams, the No. 1 overall pick in last year’s draft, has been so-so against Chicago’s chief rival in his two seasons. In ...

One prominent NFL insider named two teams that could potentially be interested in trading for San Francisco 49ers QB Mac ...

San Francisco 49ers quarterback Brock Purdy joins NFL Network's "Inside Training Camp Live" to provide a state of the team's ...

Right now, the Indianapolis Colts are trying to see how much gas 44-year-old Philip Rivers has left in the tank. […] ...

Explore several underrated defenses poised to deliver in favorable Week 16 matchups. Every fantasy football manager knows the stress of weekly lineup decisions, but defense and special teams (D/ST) ...

The Indianapolis Colts seemed to find their QB for at least the near future in Daniel Jones, who was having arguably the best ...

Zak Koeppel ranks all 32 squads by projected cap space and draft capital in 2026, with good news for Aaron Glenn's three-win ...

As the Indianapolis Colts look to keep their playoff hopes alive, up next for them is a home matchup with the San Francisco ...

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

The Tennessee Titans placed three safeties on injured reserve after their Week 15 loss to the 49ers, forcing emergency roster ...