Quick Answer: Chronic inflammation often feels like persistent fatigue, vague aches, stiffness, and recurring discomfort rather than the sharp pain and swelling of acute inflammation. It’s subtle, ongoing, and can affect multiple systems in the body. How Chronic Inflammation Feels Common Symptoms • Fatigue and low energy that doesn’t improve with rest Verywell Health. • Joint pain or stiffness, often worse in the morning Verywell Health. • Digestive issues like bloating, constipation, or diarrhe